Benefits

• Pain relief (pelvic/period pain): Many patients report less pain when using cannabis products (often high-CBD), though CBD-only RCT evidence is still pending.

• Reduced need for other pain meds (incl. opioids/NSAIDs): Surveys show large proportions of endometriosis patients cut back on analgesics when using cannabinoid products. PMCSpringerLink

• Better GI symptoms and mood/sleep: Observational data link cannabinoid use to improvements in bloating/GI discomfort, mood, and sleep—common co-symptoms in endometriosis. PMC

• Anti-inflammatory & anti-angiogenic effects (mechanistic/preclinical): In animal and cellular models, CBD reduced lesion size, inflammation, oxidative stress, and angiogenesis—mechanisms relevant to endometriosis pain and progression. PMC+1ScienceDirect+1

• Pelvic floor muscle relaxation (theoretical/early evidence): Reviews suggest CBD may help hyperalgesia/allodynia and high-tone pelvic floor dysfunction, which can contribute to pelvic pain. Human data are limited. MDPI

• Menstrual-pain support (not endo-specific but relevant): A quasi-experimental study of a high-CBD suppository reported reduced period pain and fewer analgesics vs. usual care. Nature

• Active clinical trials (evidence incoming): Multiple RCTs are underway testing high-CBD products for endometriosis pain (e.g., ENDOCAN-1 dosing study; high-CBD sublingual/placebo trials).